Rabbit Anti-TRIP4/FITC Conjugated antibody

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Activating signal cointegrator 1; ASC1; ASC 1; ASC-1; HsT17391; Thyroid hormone receptor interactor 4; Thyroid receptor interacting protein 4; Thyroid receptor-interacting protein 4; TR-interacting protein 4; TRIP 4; TRIP-4; TRIP4; TRIP4_HUMAN.

Cat:

SL7118R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human TRIP4/ASC (201-300aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

Flow-Cyt=1:50-200ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

66kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Activating signal co-integrator-1 (ASSLC1), originally identified as TRIP4, is a transcriptional co-activator of nuclear receptors that associates with specific components of the RNA polymerase II complex and binds the basal transcription factors TBP and TFIIA. ASSLC1 functions with the transcription integrators SRSLC1 and CBP/p300 through its zinc finger motif and is dependent on their ligand-dependent transactivation domain, AF2. Endogenous ASSLC1 in HeLa cells is predominantly a nuclear protein. Under conditions of serum starvation, ASSLC1 localizes to the cytoplasm. However, when serum starved in the presence of ligand of coexpressed CBP or SRSLC1, ASSLC1 remains in the nucleus. This behavior of ASSLC1 suggests that it may play an important role in establishing distinct co-activator complexes under different cellular conditions.

Function:
Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRSLC1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function.

Subunit:
Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction requires the presence of thyroid hormone. Exists as a steady-state complex associated with ASCC1, ASCC2 and HELIC1. Interacts with the androgen receptor androgen (AR) in an androgen, testosterone and dihydrotestosterone-dependent manner (By similarity). Interacts with NEK6.

Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic under conditions of serum deprivation. Co-localizes with NEK6 in the centrosome.

Post-translational modifications:
Phosphorylated by NEK6.

Database links:

Entrez Gene: 9325 Human

Entrez Gene: 51284 Mouse

Omim: 604501 Human

SwissProt: Q15650 Human

SwissProt: Q9QXN3 Mouse

Unigene: 500340 Human

Unigene: 208379 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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