background:
May regulate IL2 production by T-cells. May be involved in neuron regeneration.
Function:
May regulate IL2 production by T-cells. May be involved in neuron regeneration.
Subcellular Location:
Nucleus outer membrane.
Tissue Specificity:
Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.
DISEASE:
Note=A chromosomal aberration disrupting NAV3 has been found in patients with Sezary syndrome. Translocation t(12;18)(q21;q21.2).
Similarity:
Sequence similarities; Belongs to the Nav/unc-53 family.
Contains 1 CH (calponin-homology) domain.
Database links:
Entrez Gene: 89795 Human
Entrez Gene: 260315 Mouse
Entrez Gene: 314814 Rat
Omim: 611629 Human
SwissProt: Q8IVL0 Human
SwissProt: Q80TN7 Mouse
Unigene: 655301 Human
Unigene: 225050 Mouse
Unigene: 394160 Mouse
Unigene: 46256 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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