background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008].
Function:
KCNG1 is a member of the potassium channel, voltage-gated, subfamily G. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene is abundantly expressed in skeletal muscle. Alternative splicing results in at least two transcript variants encoding distinct isoforms.
Subunit:
Heterotetramer of potassium channel proteins (By similarity).
Subcellular Location:
Membrane; multi-pass membrane protein
Tissue Specificity:
Detected in brain and placenta, and at much lower levels in kidney and pancreas.
Similarity:
Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily.
Database links:
Entrez Gene: 3755 Human
Entrez Gene: 241794 Mouse
Entrez Gene: 296395 Rat
Omim: 603788 Human
SwissProt: Q9UIX4 Human
SwissProt: A2BDX4 Mouse
Unigene: 118695 Human
Unigene: 91149 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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