Home
>
Product
>
Antibody
>
Rabbit Anti-Kv2.2/FITC Conjugated antibody
background:
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits (KV), which include the KV1, KV2, KV3, KV4 and KV9 proteins, and accessory or KSLVsubunits that modify the gating properties of the coexpressed KV subunits. KV2.2 is a multi-pass membrane protein that regulates the voltage-dependent K+ permeability of excitable membranes. Its tail may be influential in the targeting of the channel to specific subcellular compartments and/or the regulation of channel activity.
Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
Subunit:
Heteromultimer with KCNS1, KCNS2 and KCNS3 (By similarity).
Subcellular Location:
Membrane; Multi-pass membrane protein.
Post-translational modifications:
Phosphorylated.
Similarity:
Belongs to the potassium channel family.
B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
Database links:
Entrez Gene: 9312 Human
Entrez Gene: 98741 Mouse
Entrez Gene: 117105 Rat
Omim: 607738 Human
SwissProt: Q92953 Human
SwissProt: A6H8H5 Mouse
SwissProt: Q63099 Rat
Unigene: 661102 Human
Unigene: 6702 Human
Unigene: 156081 Mouse
Unigene: 382301 Mouse
Unigene: 32101 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
