Rabbit Anti-Kv beta 2/FITC Conjugated antibody

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AKR6A5; HKv beta 2; HKvbeta 2; HKvbeta2.1; HKvbeta2.2; K(+) channel subunit beta 2; K+ channel beta 2 subunit; KCNA2B; KCNAB 2; KCNAB2; KCNK2; Kv Beta 2; Kvbeta2; MGC117289; Potassium channel shaker chain beta 2; Potassium voltage gated channel shaker rel

Cat:

SL12182R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Dog,Pig,Cow,Rabbit,Zebrafish,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human KCNA2B/Kv beta 2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

41kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]

Function:
Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence related potassium channel genes: shaker, shaw, shab, and shal, have been identified in Drosophila, and each has been shown to have human homolog(s). This protein belongs to the potassium channel, voltage gated, shaker related subfamily and is one of the beta subunits, which are auxiliary proteins associating with functional Kv alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Subunit:
Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).

Subcellular Location:
Cytoplasmic

Post-translational modifications:
Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1 (By similarity).

Similarity:
Belongs to the shaker potassium channel beta subunit family.

Database links:

Entrez Gene: 8514 Human

Entrez Gene: 16498 Mouse

Entrez Gene: 29738 Rat

Omim: 601142 Human

SwissProt: Q13303 Human

SwissProt: P62482 Mouse

SwissProt: Q3UPV6 Mouse

SwissProt: q64284 Mouse

SwissProt: P62483 Rat

Unigene: 88497 Human

Unigene: 10757 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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