Rabbit Anti-KIR5.1/FITC Conjugated antibody

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6430410F18Rik; AI132396; BIR9; Inward rectifier K channel Kir5.1; Inward rectifier K(+) channel Kir5.1; Inward rectifier potassium channel 16; IRK16; IRKG; KCNJ16; MGC33717; Potassium channel inwardly rectifying subfamily J member 16; Potassium inwardly r

Cat:

SL12179R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human KIR5.1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

48kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The KIR family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. Kir4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. Kir4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human Kir4.1 maps to chromosome 1. Kir4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human Kir4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and Kir4.2 may play a role in the pathogenesis of Down’s syndrome. Kir 5.1 forms functional channels only by coexpression with either Kir4.1 or Kir4.2 in the kidney and pancreas. The gene encoding human Kir5.1 maps to chromosome 17.

Function:
KIR5.1 is one of 20 members of the inwardly rectifying potassium (Kir) channel family. Due to its expression in kidney, pancreas and thyroid gland, it has been suggested that human KIR5.1 may be involved in the regulation of fluid and pH balance, thus making it a potential therapeutic target for hypertension, renal failure, or pancreatic disease.

Subunit:
Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.

Subcellular Location:
Membrane; Multi pass membrane protein.

Tissue Specificity:
Highly expressed in kidney, pancreas and thyroid gland.

Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily.

Database links:

Entrez Gene: 3773 Human

Entrez Gene: 16517 Mouse

Entrez Gene: 29719 Rat

Omim: 605722 Human

SwissProt: Q9NPI9 Human

SwissProt: Q9Z307 Mouse

SwissProt: P52191 Rat

Unigene: 463985 Human

Unigene: 1989 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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