Rabbit Anti-NR5A2/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-NR5A2/FITC Conjugated antibody

NR5A2/LRH1; Alpha-1-fetoprotein transcription factor; B1-binding factor; B1F; B1F2; CPF; CYP7A promoter-binding factor; FTF; FTZ F1; FTZ F1beta; FTZ-F1; FTZ-F1beta; hB1F 2; HB1F; hB1F-2; Hepatocytic transcription factor; Liver receptor homolog 1; LRH-1; L

Cat:

SL10444R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Chicken,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human NR5A2/LRH1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

61kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
NR5A2 is a pre-adipocyte-specific nuclear receptor that regulates expression of aromatase in adipose tissue. NR5A2 belongs to the fushi tarazu factor-1 subfamily of orphan nuclear receptors. NR5A2 transcripts are abundant in the human ovary and testis and are predominantly expressed in tissues of endodermal origin. NR5A2 is a positive transcription factor for ABCG5 and ABCG8 and regulates genes involved in sterol and bile acid secretion from liver and intestine. It induces cell proliferation through the concomitant induction of cyclin D1 and E1, an effect that is potentiated by its interaction with beta-catenin.

Function:
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

Subcellular Location:
Nucleus.

Tissue Specificity:
Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in hepG2. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and hepG2 cells.

Similarity:
Belongs to the nuclear hormone receptor family. NR5 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 541305 Cow

Entrez Gene: 2494 Human

Entrez Gene: 26424 Mouse

Entrez Gene: 60349 Rat

Omim: 604453 Human

SwissProt: O00482 Human

SwissProt: P45448 Mouse

SwissProt: Q9QWM1 Rat

Unigene: 33446 Human

Unigene: 16794 Mouse

Unigene: 42941 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall