Rabbit Anti-FOXD1/FITC Conjugated antibody

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Brain Factor 2; FKH L8; FKHL 8; FKHL8; Forkhead (Drosophila) like 8; Forkhead box D1; Forkhead box protein D1; Forkhead drosophila homolog like 8; Forkhead like 8; Forkhead related activator 4; Forkhead related protein FKHL8; Forkhead related transcriptio

Cat:

SL12193R-FITC

Species Reactivity：

(predicted: Human,Mouse,Chicken,Dog,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from Human FOXD1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

46kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
FOXD1 is involved in regulating inflammation as well as kidney and retinal development. FOXD1 regulates the activity of NFAT and NFkB. Deficiency of FOXD1 results in multiorgan systemic inflammation, exaggerated Th cell-derived cytokine production, and T cell proliferation in autogolgous MLRs. In kidneys, FOXD1 controls the production of signals required for the normal transition of induced mesenchyme into tubular epithelium and full growth and branching of the collecting system. Deletion of FOXD1 results in renal abnormalities. FOXD2 acts as a modulator of T cell activation.

Function:
Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly.

Subcellular Location:
Nucleus.

Similarity:
Contains 1 fork-head DNA-binding domain.

Database links:

Entrez Gene: 2297 Human

Entrez Gene: 15229 Mouse

GenBank: NP_004463 Human

Omim: 601091 Human

SwissProt: Q16676 Human

SwissProt: Q61345 Mouse

Unigene: 519385 Human

Unigene: 347441 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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