Rabbit Anti-MUC5AC/FITC Conjugated antibody

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MUC5AC Glycoprotein; Gastric Mucin M1; Apomucin; Major Airway Glycoprotein; MUC 5; MUC5; Mucin 5 subtype AC tracheobronchial; Mucin 5 Subtypes A And C; Mucin 5 subtypes A and C tracheobronchial/gastric; TBM; Tracheobronchial Mucin.

Cat:

SL7166R-FITC

Species Reactivity：

Human,Rat,(predicted: Mouse,Dog,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human MUC5AC/Mucin 5AC

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

523kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Mucin is a high M.W. (>1,000 kDa) glycoprotein, expressed by mucus cells of the gastric epithelium and by goblet cells of the fetal, precancerous and cancerous colon, but not by those of the normal colon. It also appears in other epithelial tissues, which are embryologically derived from the foregut (epigastric and bronchial epithelium) and in Müller ducts (mucus cells of the endocervix and urethral epithelium near the prostatic utriculus). The expression of MUC5AC has been frequently observed in gastric carcinomas and may be used as a marker of gastric differentiation.

Function:
Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.

Subunit:
Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).

Subcellular Location:
Secreted; Cytoplasmic and cell surface

Tissue Specificity:
Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.

Post-translational modifications:
SLC, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. SLCmannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.
Proteolytic cleavage in the SLCterminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.

Similarity:
Contains 1 CTCK (SLCterminal cystine knot-like) domain.
Contains 2 VWFC domains.
Contains 4 VWFD domains.

Database links:

Entrez Gene: 4586 Human

Entrez Gene: 17833 Mouse

Entrez Gene: 682837 Rat

Omim: 158373 Human

SwissProt: P19688 Human

Unigene: 534332 Human

Unigene: 10789 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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