Home > Product > Antibody > Rabbit Anti-ZNF350/FITC Conjugated antibody
KRAB zinc finger protein ZFQR; ZBRK1; ZFQR; Zinc finger and BRCA1 interacting protein with a KRAB domain 1; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; Zinc finger protein 350; Zinc finger protein ZBRK1; ZN350_HUMAN; ZNF350.
Cat:
SL12213R-FITC
Species Reactivity:
(predicted: Human,)
Immunogen:
KLH conjugated synthetic peptide derived from Human ZNF350/ZBRK1
Format:
Lyophilized or Liquid
Storage instructions:
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration:
1mg/ml
Clonality:
Polyclonal
Isotype:
IgG
Applications:
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host:
Rabbit
Calculated MW:
60kDa
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Unit:
Price: $
Product PDFs
Datasheet:


background:
The transcpritional repressor ZBRK1, also designated zinc finger and BRCA1-interacting protein with a KRAB domain 1 or zinc finger protein 350, belongs to the Krüppel C2H2-type zinc-finger protein family of proteins. ZBRK1 localizes mainly to the nucleus and may be associated with the nuclear matrix. It is a widely expressed protein that binds to BRCA1. ZBRK1 plays an important role in transcriptional regulation. Likely targets of gene regulation are DNA damage response genes, which effect the survival and growth control of cells. ZBRK1 contains an N-terminal KRAB domain, a SLCterminal BRCA1-binding region and eight central zinc-fingers.

Function:
Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.

Subunit:
Interacts with BRCA1. Interacts with RNF11.

Subcellular Location:
Nucleus matrix. Associated with the nuclear matrix.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 8 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Database links:

Entrez Gene: 59348 Human

Entrez Gene: 234358 Mouse

Entrez Gene: 100158232 Rat

Omim: 605422 Human

SwissProt: Q9GZX5 Human

Unigene: 407694 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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