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Rabbit Anti-USE1/FITC Conjugated antibody
background:
In eukaryotic cells, the Golgi apparatus receives newly synthesized proteins from the endoplasmic reticulum (ER) and, after covalent modification, delivers them to their destination in the cell. For membrane-directed proteins this process is believed to be carried out via vesicular transport. Correct vesicular transport is determined by specific pairing of vesicle-associated SNAREs (v-SNAREs) with those on the target membrane (t-SNAREs). Unconventional SNARE in the ER 1, also known as USE1 or protein p31, is a 259 amino acid t-SNARE that forms a larger complex with ZW10, RINT-1 and Syntaxin 18. Upon Mg2+-AP treatment in the presence of NSF and ?SNAP, ZW10, RINT-1 and USE1 dissociate from Syntaxin 18. USE1 is a single-pass type IV membrane protein that is localized to the endoplasmic reticulum membrane. Three named isoforms exist for USE1 as a result of alternative splicing events.
Function:
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Subunit:
Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18.
Subcellular Location:
Endoplasmic reticulum membrane.
Similarity:
Belongs to the USE1 family.
Database links:
Entrez Gene: 512890 Cow
Entrez Gene: 55850 Human
Entrez Gene: 67023 Mouse
Entrez Gene: 290627 Rat
Omim: 610675 Human
SwissProt: Q9NZ43 Human
SwissProt: Q9CQ56 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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