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Rabbit Anti-Fox2/FITC Conjugated antibody
background:
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.
Subunit:
Interacts with ER-alpha N-terminal activation domain.
Subcellular Location:
Nucleus. Cytoplasm.
Similarity:
Contains 1 RRM (RNA recognition motif) domain.
Database links:
Entrez Gene: 23543 Human
Entrez Gene: 93686 Mouse
Omim: 612149 Human
SwissProt: O43251 Human
SwissProt: Q8BP71 Mouse
Unigene: 282998 Human
Unigene: 202774 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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