background:
Phocein is a 225 amino acid protein encoded by the human gene MOBKL3. Phocein belongs to the MOB1/phocein family and is phosphorylated on serine residues. Phocein is a widely expressed, highly conserved intracellular protein. The sequence of Phocein has limited homology to the sigma subunits from Clathrin adaptor complexes and contains an additional stretch bearing a putative SH3-binding domain. Phocein is usually associated with membranes but can be present in the cytosol, where it behaves as a protein complex. Phocein is the major partner of the striatin family members, which are scaffolding proteins involved in signaling and trafficking. Due to its association with Dynamin via direct interactions with nucleotide diphosphate kinase (NDPK) and Eps15, Phocein has been implicated in vesicular trafficking, acting in particular in the endocytic process.
Function:
May play a role in membrane trafficking, specifically in membrane budding reactions.
Subunit:
Binds STRN4. Interacts with DNM1 and EPS15 (By similarity). Interacts with nucleoside diphosphate kinase (By similarity). Binds STRN and STRN3. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Phosphorylated on serine residues.
Similarity:
Belongs to the MOB1/phocein family.
Database links:
Entrez Gene: 25843 Human
Entrez Gene: 19070 Mouse
Entrez Gene: 613127 Pig
Entrez Gene: 171050 Rat
Entrez Gene: 45807 Chicken
Entrez Gene: 781884 Cow
Omim: 609361 Human
SwissProt: Q5F495 Chicken
SwissProt: Q9Y3A3 Human
SwissProt: Q6PEB6 Mouse
SwissProt: Q9QYW3 Rat
Unigene: 633165 Human
Unigene: 645458 Human
Unigene: 291037 Mouse
Unigene: 46648 Mouse
Unigene: 12262 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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