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Rabbit Anti-TUG/FITC Conjugated antibody
background:
Glut4 is a twelve pass transmembrane protein (12TM) whose carboxy-terminus may dictate its cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity. TUG (ASPL in humans) regulates the trafficking of glucose via Glut4. Full-length TUG forms a complex with Glut4 and in 3T3-L1 adipocytes and this complex is present in unstimulated cells and is disassembled by insulin. TUG acts by trapping endocytosed Glut4 and tethering it intracellularly. Insulin mobilizes this pool of retained Glut4 by releasing the tether.
Function:
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface.
Subunit:
Interacts with GLUT4 (By similarity).
Subcellular Location:
Endomembrane system; Peripheral membrane protein (By similarity).
Tissue Specificity:
Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.
DISEASE:
Note=A chromosomal aberration involving ASPSCR1 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein.
Note=A chromosomal aberration involving ASPSCR1 has been found in two patients with of papillary renal cell carcinoma. Translocation t(X;17)(p11.2;q25).
Similarity:
Contains 1 UBX domain.
Database links:
Entrez Gene: 79058 Human
Entrez Gene: 68938 Mouse
Entrez Gene: 691026 Rat
Omim: 606236 Human
SwissProt: Q9BZE9 Human
SwissProt: Q8VBT9 Mouse
Unigene: 298351 Human
Unigene: 294020 Mouse
Unigene: 20298 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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