background:
Mig-2 recruits migfilin to cell-matrix adhesions, while the interaction with filamin mediates the association of migfilin with actin filaments. Together, Mig-2, migfilin and filamin define a connection between cell matrix adhesions and the actin cytoskeleton and participate in the orchestration of actin assembly and cell shape modulation. Mig-2 expression is transcriptionally elevated in leiomyomas and could be involved in its hormone-mediated growth of leiomyomas of the uterus. Expression of Mig-2 is ubiquitous, and it is found in numerous tumor tissues.
Function:
Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites.
Subunit:
Interacts with FBLP1.
Subcellular Location:
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Note=Within actin stress fibers at cell-ECM focal adhesion sites.
Tissue Specificity:
Ubiquitous. Found in numerous tumor tissues.
Similarity:
Belongs to the kindlin family.
Contains 1 FERM domain.
Contains 1 PH domain.
Database links:
Entrez Gene: 10979 Human
Entrez Gene: 218952 Mouse
Entrez Gene: 289992 Rat
Entrez Gene: 616981 Cow
Omim: 607746 Human
SwissProt: Q96AC1 Human
SwissProt: Q8CIB5 Mouse
Unigene: 509343 Human
Unigene: 210018 Mouse
Unigene: 7658 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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