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Rabbit Anti-14-3-3 beta/FITC Conjugated antibody
background:
14-3-3 are activates tyrosine and tryptophan hydroxylases in the presence of Ca (2+)/calmodulin-dependent protein kinase II, and strongly activates protein kinase C. Is probably a multifunctional regulator of the cell signaling processes mediated by both kinases. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin. 14-3-3 proteins are localized in neurons, and are axonally transported to the nerve terminals. They may be also present, at lower levels, in various other eukaryotic tissues. It belongs to the 14-3-3 family.
This antibody is reactive with 14-3-3 Alpha/Beta/Gamma/Delta/Epsilon.
Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.
Subcellular Location:
Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Post-translational modifications:
The alpha, brain-specific form differs from the beta form in being phosphorylated.
Isoform Short contains a N-acetylmethionine at position 1.
Similarity:
Belongs to the 14-3-3 family.
Database links:
Entrez Gene: 7529 Human
Entrez Gene: 5881 Mouse
Entrez Gene: 56011 Rat
Omim: 601289 Human
SwissProt: P31946 Human
SwissProt: Q9CQV8 Mouse
SwissProt: P35213 Rat
Unigene: 643544 Human
Unigene: 34319 Mouse
Unigene: 485025 Mouse
Unigene: 8653 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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