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Rabbit Anti-DAAM2/FITC Conjugated antibody
background:
DAAM2 is a widely expressed 1,068 amino acid protein that contains one DAD domain, one FH1 domain, one FH2 domain and one GBD domain, through which it may play a role in Wnt/Frizzled-associated signaling events. The gene encoding DAAM2 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.
Tissue Specificity:
Expressed in most tissues examined.
Similarity:
Belongs to the formin homology family.
Contains 1 DAD (diaphanous autoregulatory) domain.
Contains 1 FH1 (formin homology 1) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Database links:
Entrez Gene: 23500 Human
Entrez Gene: 76441 Mouse
Entrez
Gene: 316201 Rat
Omim: 606627 Human
SwissProt: Q86T65 Human
SwissProt: Q80U19 Mouse
Unigene: 357128 Human
Unigene: 718492 Human
Unigene: 211275 Mouse
Unigene: 129337 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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