Home
>
Product
>
Antibody
>
Rabbit Anti-ALDH1A2/FITC Conjugated antibody
background:
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011].
Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently.
Subunit:
Homotetramer.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the aldehyde dehydrogenase family.
Database links:
Entrez Gene: 8854 Human
Entrez Gene: 19378 Mouse
Entrez Gene: 116676 Rat
Omim: 603687 Human
SwissProt: O94788 Human
SwissProt: Q62148 Mouse
SwissProt: Q63639 Rat
Unigene: 643455 Human
Unigene: 42016 Mouse
Unigene: 10514 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|