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Rabbit Anti-ADH6/FITC Conjugated antibody
background:
ADH6 (alcohol dehydrogenase 6), also known as ADH-5, is a 368 amino acid member of the class V zinc-containing alcohol dehydrogenase family. This family of enzymes functions to metabolize a wide variety of substrates such as retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. Localized to the cytoplasm and expressed in the stomach and liver, ADH6 catalyzes the reversible oxidation of alcohols to their corresponding aldehydes or ketones and is able to bind two zinc ions as cofactors. ADH6 contains a glucocorticoid response element upstream of its 5' UTR which is thought to be a steroid binding site, suggesting that expression of ADH6 may be under hormonal control. Multiple isoforms of ADH6 exist due to alternative splicing events.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Stomach and liver.
Similarity:
Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily.
Database links:
Entrez Gene: 130 Human
Entrez Gene: 310903 Rat
Omim: 103735 Human
SwissProt: P28332 Human
SwissProt: Q5XI95 Rat
Unigene: 586161 Human
Unigene: 214994 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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