background:
Syntaxins were originally thought to be docking proteins, but have more recently been categorized as anchoring proteins that anchor themselves to the cytoplasmic surfaces of cellular membranes. Syntaxins have been shown to bind to various proteins involved in exocytosis, including VAMPs (vesicle-associated membrane proteins), NSF (N-ethylmaleimide-sensitive factor), SNAP 25 (synaptosomal-associated protein of 25kDa), SNAPs (soluble NSF attachment proteins) and synaptotagmin. VAMPs (also designated synaptobrevins), including VAMP-1 and VAMP-2, and synaptotagmin, a protein that may function as an inhibitor of exocytosis, are vesicular proteins.
Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subunit:
Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12 (By similarity).
Subcellular Location:
Membrane; Peripheral membrane protein.
Similarity:
Belongs to the SNAP family.
Database links:
Entrez Gene: 511687 Cow
Entrez Gene: 8775 Human
Entrez Gene: 108124 Mouse
Entrez Gene: 140673 Rat
Omim: 603215 Human
SwissProt: P81125 Cow
SwissProt: P54920 Human
SwissProt: Q9DB05 Mouse
SwissProt: P54921 Rat
Unigene: 126938 Human
Unigene: 727492 Human
Unigene: 104540 Mouse
Unigene: 431371 Mouse
Unigene: 31745 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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