background:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
Function:
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
Subunit:
Interacts (via N-terminus) with AIMP1 (via N-terminus); this stimulates its catalytic activity. Interacts (via N-terminus) with LARS2 (via SLCterminus). Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the class-I aminoacyl-tRNA synthetase family.
Database links:
Entrez Gene: 5917 Human
Entrez Gene: 104458 Mouse
Entrez Gene: 287191 Rat
Omim: 107820 Human
SwissProt: P54136 Human
SwissProt: Q9D0I9 Mouse
SwissProt: P40329 Rat
Unigene: 654907 Human
Unigene: 284906 Mouse
Unigene: 18711 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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