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Rabbit Anti-ARVCF/FITC Conjugated antibody
background:
Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010].
Function:
Involved in protein-protein interactions at adherens junctions.
Subunit:
Interacts (via the extreme SLCterminus) with FRMPD2 (via the PDZ 2 domain).
Tissue Specificity:
Found in all the examined tissues including heart, brain, liver and kidney. Found at low level in lung.
Similarity:
Belongs to the beta-catenin family.
Contains 10 ARM repeats.
Database links:
Entrez Gene: 421 Human
Omim: 602269 Human
SwissProt: O00192 Human
Unigene: 699354 Human
Unigene: 713616 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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