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Rabbit Anti-ATF6 beta/FITC Conjugated antibody
background:
ATF-6 is a member of the basic-leucine zipper family of transcription factors. Endoplasmic reticulum stress causes cleavage of transmembrane ATF-6 and transclocation of active ATF-6 to the nucleus. Soluble ATF-6 can exist as either an ATF-6beta homodimer or an ATF-6Alpha/beta heterodimer. Binding of the ATF-6beta homodimer or ATF-6Alpha/beta heterodimer to the nuclear transcription factor Y C (NF-YC) induces ER chaperone transcription.
Function:
Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.
Subunit:
Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC).
Subcellular Location:
Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
N-glycosylated.
During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.
Similarity:
Belongs to the bZIP family. ATF subfamily.
Contains 1 bZIP domain.
Database links:
Entrez Gene: 1388 Human
Entrez Gene: 12915 Mouse
Entrez Gene: 406169 Rat
Omim: 600984 Human
SwissProt: Q5SSW7 Human
SwissProt: Q99941 Human
SwissProt: O35451 Mouse
SwissProt: Q4G097 Rat
SwissProt: Q6MG80 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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