background:
BIVM (for basic, immunoglobulin like variable motif containing) refers to a recently identified gene product that maps to human chromosome 13q32-q33 and is predicted to encode a 503 amino acid protein. BIVM shows ubiquitous expression in normal human tissue and the presence of a 5' CpG island suggests it is a housekeeping gene. BIVM is likely essential for some aspect of basic cellular function. BIVM is highly charged and localizes to the cytoplasm and nucleus where it may bind to either DNA or RNA or associate with other cellular proteins. Significant sequence homology exists with many organisms.
Subcellular Location:
Cytoplasmic and Nuclear
Tissue Specificity:
Widely expressed. Expressed at higher level in spleen, ovary, small intestine, colon, peripheral blood leukocytesand liver. Also expressed in testis, ovary, aorta, appendix,trachea, pituitary gland, bladder, uterus, spinal cord, salivarygland, stomach, mammary gland and bone marrow. Weakly or notexpressed in fetal spleen, adult thymus and certain cancer celllines.
Similarity:
Belongs to the BIVM family.
Database links:
Entrez Gene: 54841 Human
Entrez Gene: 246229 Mouse
SwissProt: Q86UB2 Human
SwissProt: Q8CBX9 Mouse
Unigene: 281769 Human
Unigene: 386883 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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