Rabbit Anti-BOP1/FITC Conjugated antibody

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AU020183; AW146150; Block of proliferation 1; Block of proliferation 1 protein; Bop1; Bop1 block of proliferation 1; BOP1_HUMAN; D18861; Erb1p; Kiaa0124; MGC109114; mKIAA0124; Ribosome biogenesis protein BOP1.

Cat:

SL12877R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Chicken,Dog,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human BOP1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

84kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis.

Function:
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Subunit:
Component of the PeBoW complex, composed of BOP1, PES1and WDR12. Within the PeBoW complex BOP1 interacts directly withPES1 and WDR12. The PeBoW complex also associates with the 66Spre-ribosome.

Subcellular Location:
Nucleus

Similarity:
Belongs to the WD repeat BOP1/ERB1 family.
Contains 7 WD repeats.

Database links:

Entrez Gene: 23246 Human

Entrez Gene: 12181 Mouse

Entrez Gene: 300050 Rat

Omim: 610596 Human

SwissProt: Q14137 Human

SwissProt: P97452 Mouse

SwissProt: Q562C2 Rat

Unigene: 645279 Human

Unigene: 4283 Mouse

Unigene: 101388 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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