Rabbit Anti-CRTC3/FITC Conjugated antibody

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CREB regulated transcription coactivator 3; CREB-regulated transcription coactivator 3; CRTC 3; CRTC3; CRTC3_HUMAN; FLJ21868; TORC 3; TORC-3; TORC3; Transducer of CREB protein 3; Transducer of regulated cAMP response element binding protein (CREB) 3; Tran

Cat:

SL12950R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CRTC3/TORC3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

67kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
TORC3 is a 619 amino acid protein that localizes to both the cytoplasm and the nucleus and belongs to the TORC family. Expressed in lung tissue and B and T lymphocytes, as well as in colon, brain, ovary, kidney, prostate, colon and heart, TORC3 functions as a transcriptional coactivator for CREB-1, thereby regulating the expression of CREB-activated genes, and is also thought to activate the SIK/TORC signaling pathway. TORC3 exists as multiple alternatively spliced isoforms and, in addition to its role in transcriptional activation, is thought to induce mitochondrial biogenesis, specifically in muscle cells.

Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLSLV1) long terminal repeats (LTR).

Subunit:
Binding, as a tetramer, through its N-terminal region,with the bZIP domain of CREB1 enhances recruitment of TAF4 to thepromoter. 'Arg-314' in the bZIP domain of CREB1 is essential forthis interaction (By similarity). Interaction with HTLSLV1 TAXenhances its transcriptional activity. Interacts, via theN-terminal with the ankyrin repeats of BCL3, to form a complex withCREB1 on CRE and TxRE responsive elements and represses HTLSLV1LTR-mediated transcription.

Subcellular Location:
Nucleus. Cytoplasm. Appears to be mainly nuclear.

Tissue Specificity:
Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.

Similarity:
Belongs to the TORC family.

Database links:

Entrez Gene: 64784 Human

Entrez Gene: 70461 Mouse

Entrez Gene: 365297 Rat

Omim: 608986 Human

SwissProt: Q6UUV7 Human

SwissProt: Q91X84 Mouse

Unigene: 567572 Human

Unigene: 392175 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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