background:
CTRP2 is a 285 amino acid secreted protein that contains one C1q domain and one collagen-like domain and is encoded by a gene that maps to human chromosome 5. Chromosome 5 contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Subcellular Location:
Secreted.
Similarity:
Contains 1 C1q domain.
Contains 1 collagen-like domain.
Database links:
Entrez Gene: 114898 Human
Entrez Gene: 69183 Mouse
Entrez Gene: 497886 Rat
SwissProt: Q9BXJ5 Human
SwissProt: Q9D8U4 Mouse
Unigene: 110062 Human
Unigene: 390374 Mouse
Unigene: 107489 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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