Rabbit Anti-MUC13/FITC Conjugated antibody

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MUC13 Down regulated in colon cancer 1; DRCC1; MUC 13; MUC-13; Mucin 13, cell surface associated; RECC; UNQ6194; MUC13_HUMAN.

Cat:

SL10074R-FITC

Species Reactivity：

Human,Mouse,(predicted: Rat,Pig,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human MUC13

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

54kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
MUC13 is a mucin. These are secreted or transmembrane glycoproteins that are expressed mainly in the digestive tract and on epithelial surfaces. MUC13 is upregulated in gastric cancer. Mucins have also been implicated in inflammatory bowel diseases.

Function:
Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

Subunit:
Homodimer of beta subunits.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Potential). Secreted. Note=Also exists as a soluble form.

Tissue Specificity:
Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.

Post-translational modifications:
Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homo-oligomerization into dimers is dependent on intrachain disulfide bonds.
Highly N-glycosylated.

Similarity:
Contains 3 EGF-like domains.
Contains 1 SEA domain.

Database links:

Entrez Gene: 56667 Human

Omim: 612181 Human

SwissProt: Q9H3R2 Human

Unigene: 5940 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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