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Rabbit Anti-FOXI1/FITC Conjugated antibody
background:
FOXI1 is a member of the FOX family of transcription factors. The FOX family is a large group of proteins (consisting of at least 43 members) that share a common DNA binding domain termed winged-helix or forkhead domain. FOX transcription factors play important roles in development, differentiation, aging and hormone responsiveness. Localizing to the nucleus, FOXI1 functions as a transcription factor. Mice with mutated forms of FOXI1 show defects in ear development, implying that FOXI1 plays a significant role in the developmental pathway of ears and, in particular, the cochlea and vestibulum. FOXI1 is an upstream transcription regulator of Pendrin (a protein associated with deafness), suggesting a role for FOXI1 in the pathogenesis of Pendred syndrome (PS), a condition of nonsyndromic hearing loss and enlarged vestibular aqueduct (EVA).
Function:
FOXI1 belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene.
Subcellular Location:
Nuclear.
Tissue Specificity:
Expressed in kidney.
Similarity:
Contains 1 fork-head DNA-binding domain.
Database links:
Entrez Gene: 2299 Human
Entrez Gene: 14233 Mouse
Entrez Gene: 287185 Rat
Omim: 601093 Human
SwissProt: Q12951 Human
SwissProt: Q922I5 Mouse
Unigene: 87236 Human
Unigene: 32926 Mouse
Unigene: 32116 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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