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Rabbit Anti-FUBP1/FITC Conjugated antibody
background:
Activation of FUSE, the far upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP1 (FUSE-binding protein or far upstream element-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP1 functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL-60 cells, FBP1 (FBP), FBP2 and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP1 is detected in undifferentiated cells and is substantially decreased following cellular differentiation.
Function:
Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.
Subunit:
Found in a complex with PUF60 and far upstream element (FUSE) DNA segment. Interacts with PUF60 and JTV1.
Subcellular Location:
Nucleus.
Post-translational modifications:
Ubiquitinated. This targets the protein for proteasome-mediated degradation.
Similarity:
Contains 4 KH domains.
Database links:
Entrez Gene: 8176 Human
Entrez Gene: 51886 Mouse
Entrez Gene: 654496 Rat
Entrez Gene: 513562 Cow
Omim: 603444 Human
SwissProt: Q96AE4 Human
SwissProt: Q91WJ8 Mouse
SwissProt: Q32PX7 Rat
Unigene: 567380 Human
Unigene: 278922 Mouse
Unigene: 177078 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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