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Rabbit Anti-SFTPA1/FITC Conjugated antibody
background:
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009].
Function:
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
Subunit:
Oligomeric complex of 6 set of homotrimers.
Subcellular Location:
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
DISEASE:
Defects in SFTPA2 are a cause of pulmonary fibrosis idiopathic (IPF) [MIM:178500]. Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease.
Similarity:
Belongs to the SFTPA family.
Contains 1 SLCtype lectin domain.
Contains 1 collagen-like domain.
Database links:
Entrez Gene: 653509 Human
Entrez Gene: 20387 Mouse
Entrez Gene: 24773 Rat
Omim: 178630 Human
SwissProt: Q8IWL2 Human
SwissProt: P35242 Mouse
SwissProt: P08427 Rat
Unigene: 535295 Human
Unigene: 9262 Mouse
Unigene: 11343 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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