background:
G3BP2 (GTPase activating protein (SH3 domain) binding protein 2) is a 482 amino acid protein that localizes to the cytoplasm and contains one NTF2 domain and one RRM domain. Existing as two alternatively spliced isoforms, G3BP2 acts as a scaffold protein that is thought to be involved in mRNA transport and is subject to post-translational methylation on select arginine residues. The gene encoding G3BP2 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Function:
Probable scaffold protein that may be involved in mRNA transport.
Subunit:
Binds to the N-terminal domain of I-kappa-B-alpha.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
Similarity:
Contains 1 NTF2 domain.
Contains 1 RRM (RNA recognition motif) domain.
Database links:
Entrez Gene: 9908 Human
Entrez Gene: 23881 Mouse
Entrez Gene: 30548 Rat
SwissProt: Q9UN86 Human
SwissProt: P97379 Mouse
SwissProt: Q5R9L3 Orangutan
Unigene: 303676 Human
Unigene: 290530 Mouse
Unigene: 473827 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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