background:
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subunit:
Interacts with VANGL2.
Subcellular Location:
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.
Post-translational modifications:
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Similarity:
Belongs to the G-protein coupled receptor Fz/Smo family.
Contains 1 FZ (frizzled) domain.
Database links:
Entrez Gene: 7976 Human
Entrez Gene: 14365 Mouse
Entrez Gene: 100153078 Pig
Entrez Gene: 100339544 Rabbit
Entrez Gene: 266715 Rat
Entrez Gene: 395572 Chicken
Entrez Gene: 445419 Cow
Entrez Gene: 486093 Dog
Entrez Gene: 100054732 Horse
Omim: 606143 Human
SwissProt: Q9NPG1 Human
SwissProt: Q61086 Mouse
Unigene: 40735 Human
Unigene: 214687 Mouse
Unigene: 404299 Mouse
Unigene: 178695 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
