Rabbit Anti-GABPB2/FITC Conjugated antibody

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MGC29891; BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B; GA binding protein transcription factor beta subunit 1 transcript variant gamma 2; GA binding protein transcription factor, beta subunit 1; GA binding protein transcription factor, beta subunit 2; GA-bi

Cat:

SL13262R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Chicken,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human GABPB2/GABPB1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

42kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The transcription factor GA-binding protein (GABP) is composed of two subunits, the Ets-related GABP-alpha and a GABP-alpha-associated subunit, GABP beta. GABP alpha binds to a specific DNA sequence and GABP beta exists as b1 and b2 splice variants that differ in their SLCtermini. In primary neuronal cultures, GABP beta is expressed in both the cytoplasm and the nucleus, whereas GABP alpha is expressed mainly in the nucleus. GABP is constitutively expressed as either a GABP alpha beta heterodimer or a GABP alpha b heterotetramer, both of which can modify GABP-dependent transcription in vitro and in vivo . The GABP alpha beta tetrameric complex performs many different functions, such as stimulating transcription of the adenovirus E4 gene, differentially activating BRCA1 expression in human breast cell lines, potentiating Tat-mediated activation of long terminal repeat promoter transcription and viral replication in certain cell types, acting as a coordinator of mitochrondrial and nuclear transcription for cytochrome oxidase in neurons and assisting in the regulation of rpL32 gene transcription.

Function:
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

Subunit:
Heterotetramer of two alpha and two beta subunits. Interacts with HCFC1, causing repression of transcriptional activity.

Subcellular Location:
Nucleus.

Similarity:
Contains 5 ANK repeats.

Database links:

Entrez Gene: 2553 Human

Entrez Gene: 14391 Mouse

Entrez Gene: 364738 Rat

Omim: 600610 Human

SwissProt: Q06547 Human

SwissProt: Q00420 Mouse

Unigene: 654350 Human

Unigene: 293266 Mouse

Unigene: 61149 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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