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Home > Product > Antibody > Rabbit Anti-SLC20A2/FITC Conjugated antibody
Gibbon ape leukemia virus receptor 2; Gibbon leukemia virus receptor 2; GLVR 2; GLVR-2; GLVR2; hPit2; IBGC3; MLVAR; Murine leukemia virus amphotropic receptor; murine leukemia virus, amphotropic, receptor for; Phosphate transporter 2; PIT 2; PiT-2; Pit2;
Cat:
SL8610R-FITC
Species Reactivity：
Mouse,(predicted: Human,Rat,Chicken,Pig,Cow,Horse,Rabbit,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human SLC20A2/PIT2
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
70kDa
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Product PDFs
Datasheet:


background:
The SLC20 family transport proteins were originally identified as retroviral receptors Glvr-1 and Ram-1, but are now designated sodium-dependent phosphate transporters 1 and 2 (PiT1 and PiT2). The PiT proteins function as sodium-phosphate cotransporters and are widely expressed, with high expression in bone, kidney and intestine. Both PiT1 and PiT2 are expressed on polarized epithelial cell membranes where they play a role in cellular phosphate homeostasis. PiT2 is a human receptor for amphotropic murine leukemia virus (A-MuLV). A-MuLV infects a variety of mammalian cell lines, including humans, making it a useful tool in gene transfer technology and as a vector for gene therapy. Retroviral vector systems are used in gene therapy that are designed to infect cells expressing PiT1 or PiT2.

Function:
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLSLVB) variants.

Subunit:
Homodimer.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Ubiquitously expressed.

DISEASE:
Defects in SLC20A2 are the cause of basal ganglia calcification, idiopathic, type 3 (IBGC3) [MIM:614540]. An autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal.

Similarity:
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.

Database links:

Entrez Gene: 6575 Human

Entrez Gene: 20516 Mouse

Entrez Gene: 29502 Rat

Omim: 158378 Human

SwissProt: Q95L97 Cat

SwissProt: Q08357 Human

SwissProt: Q80UP8 Mouse

SwissProt: Q63488 Rat

Unigene: 653173 Human

Unigene: 323901 Mouse

Unigene: 378231 Mouse

Unigene: 13642 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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