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Rabbit Anti-ADRM1/FITC Conjugated antibody
background:
ADRM1 is a 407 amino acid protein that localizes to both the nucleus and the cytoplasm and is thought to be involved in protein recruitment and cell adhesion. An integral membrane protein, ADRM1 functions to recruit UCH-L5, a deubiquitinating enzyme, to the 26S proteasome, and once at the proteasome it promotes the activity of UCH-L5. Additionally, ADRM1 is thought to mediate lymphocyte adhesion in endothelial cells and may thus play a role in lymphocyte homing. ADRM1 expression is induced by IFN-g in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis. Two isoforms of ADRM1 exist due to alternative splicing events.
Function:
Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.
Subunit:
Interacts with PSMD1, ubiquitin and UCHL5.
Subcellular Location:
Cytoplasm. Nucleus.
Similarity:
Belongs to the ADRM1 family.
Contains 1 PH domain.
Database links:
Entrez Gene: 11047 Human
Entrez Gene: 56436 Mouse
Omim: 610650 Human
SwissProt: Q16186 Human
SwissProt: Q9JKV1 Mouse
Unigene: 90107 Human
Unigene: 379082 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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