background:
LGA is a 602 amino acid protein that localizes to the mitochondrion and contains two ANK repeats. Expressed in brain, liver and pancreas, LGA functions as a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. LGA is overexpressed in breast cancer cell lines, suggesting a role for LGA in tumorigenesis. The gene encoding LGA maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.
Function:
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
Subunit:
Interacts with the PDZ domain of the syntrophin SNTA1.Interacts with the PDZ domain of TAX1BP3.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas.
Similarity:
Belongs to the glutaminase family.
Contains 2 ANK repeats.
Database links:
Entrez Gene: 27165 Human
Entrez Gene: 216456 Mouse
Entrez Gene: 192268 Rat
Omim: 606365 Human
SwissProt: Q9UI32 Human
SwissProt: Q571F8 Mouse
SwissProt: P28492 Rat
Unigene: 212606 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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