Rabbit Anti-GPBP1/FITC Conjugated antibody

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Vasculin; DKFZp761C169; GC rich promoter binding protein 1; GC-rich promoter-binding protein 1; GPBP; Gpbp1; GPBP1_HUMAN; MGC126339; SSH6; Vascular wall linked; Vascular wall-linked protein.

Cat:

SL13503R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human GPBP1/Vasculin

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

53kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Vascular wall-linked protein, or Vasculin, is primarily expressed in the arterial wall and in plasma. It is also differentially expressed in human atherogenesis. Alternative splicing of exon 3 of the Vasculin gene produces three variants. Vasculin binds to and activates the minimal self-sufficient promoter element (MSPE) of the mouse Ada gene promoter and binds to and partially suppresses the GSLCrich promoter of the nonhomologous human TOP2A gene promoter. It acts as a nuclear factor that can form complexes with TATA-binding proteins, transcription factors TFIIB and TFIIF, RNA polymerase II and p300. The regulated expression of Vasculin in plaques suggests that it may be involved in atherogenesis, and its presence in plasma may implicate Vasculin as a marker for atherosclerosis.

Function:
Functions as a GSLCrich promoter-specific transactivating transcription factor.

Subunit:
Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP (By similarity).

Subcellular Location:
Nucleus. Cytoplasm. According to PubMed:12842993, it localizes to the cytoplasm.

Tissue Specificity:
Widely expressed. Some isoforms may be specifically expressed in veins and arteries (at protein level). Isoform 4 is widely expressed. Isoform 1, isoform 2 and isoform 3 may be specifically expressed in vascular smooth muscle cells.

Similarity:
Belongs to the vasculin family.

Database links:

Entrez Gene: 65056 Human

Entrez Gene: 73274 Mouse

Entrez Gene: 294734 Rat

Entrez Gene: 613751 Cow

SwissProt: Q0P5K1 Cow

SwissProt: Q86WP2 Human

SwissProt: Q9H0D4 Human

SwissProt: Q9H785 Human

SwissProt: Q3TQR2 Mouse

SwissProt: Q6NXH3 Mouse

SwissProt: Q6TYE7 Mouse

SwissProt: Q8R252 Mouse

Unigene: 1788 Cow

Unigene: 444279 Human

Unigene: 441830 Mouse

Unigene: 57286 Mouse

Unigene: 33325 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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