background:
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq].
Function:
May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis.
Subcellular Location:
Secreted.
Similarity:
Belongs to the IL-10 family.
Database links:
Entrez Gene: 29949 Human
Entrez Gene: 329244 Mouse
Omim: 605687 Human
SwissProt: Q9UHD0 Human
SwissProt: Q8CJ70 Mouse
Unigene: 661017 Human
Unigene: 13296 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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