background:
G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an ancient evolutionarily mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. GPRs have seven membrane-spanning domains and the extracellular domains are often glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR26 (G-protein coupled receptor 26) is a 337 amino acid protein that is primarily expressed in regions of the brain. GPR26 is characterized as an ‘orphan’ G protein-coupled receptor, which is a receptor that binds an unidentified natural ligand. Due to evidence of GPR26 being downregulated in glioblastomas, it has been suggested that GPR26 may be a suppressor of early glioma development.
Function:
GPCR GPR26 is an Orphan receptor. It displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. Is highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 2849 Human
Entrez Gene: 233919 Mouse
Entrez Gene: 192153 Rat
Omim: 604847 Human
SwissProt: Q8NDV2 Human
SwissProt: Q8BZA7 Mouse
SwissProt: Q9QXI3 Rat
Unigene: 12751 Human
Unigene: 208740 Mouse
Unigene: 48779 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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