Rabbit Anti-GPR27/FITC Conjugated antibody

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G protein coupled receptor 27; GPR 27; GPR27; GPR27_HUMAN; Probable G protein coupled receptor GPR27; Probable G-protein coupled receptor 27; SREB 1; SREB1; Super conserved receptor expressed in brain 1; GPCR GPR27.

Cat:

SL13528R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human SREB1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

Flow-Cyt=1:50-200ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

40kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. GPRs all have seven membrane-spanning domains and extracellular loops that can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. SREB1 (super conserved receptor expressed in brain 1), also known as GPR27 (G protein-coupled receptor 27), belongs to the SREB subfamily of GPRs that are expressed in the central nervous system. SREB1 may function as an amine-like GPR.

Function:
Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 2850 Human

Entrez Gene: 14761 Mouse

Entrez Gene: 65275 Rat

Omim: 605187 Human

SwissProt: Q9NS67 Human

SwissProt: O54897 Mouse

SwissProt: Q9JJH3 Rat

Unigene: 591653 Human

Unigene: 35009 Mouse

Unigene: 54454 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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