Home
>
Product
>
Antibody
>
Rabbit Anti-C8orf4/FITC Conjugated antibody
background:
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
Function:
May decrease apoptosis.
Subunit:
Monomer.
Tissue Specificity:
Ubiquitous. Expressed in thyroid papillary carcinoma.
Database links:
Entrez Gene: 56892 Human
Omim: 607702 Human
SwissProt: Q9NR00 Human
Unigene: 591849 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|