background:
ZA20D3 is a zinc-finger protein located on chromosome 15. It is associated with PRK1.
Function:
Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes
Subunit:
Interacts with PKN1 (By similarity). Interacts with TRAF2. Interacts with mono- and polyubiquitin. Interacts with PEX6. Interacts with PEX5 (Cys-linked ubiquitinated) (By similarity).
Subcellular Location:
Cytoplasm
Tissue Specificity:
Widely expressed with high level in heart, skeletal muscle, liver, kidney and placenta.
Similarity:
Contains 1 A20-type zinc finger.
Contains 1 AN1-type zinc finger.
Database links:
UniProtKB/Swiss-Prot: Q6FIF0.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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