Rabbit Anti-ZNF93/FITC Conjugated antibody

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FLJ12488; HPF34; HTF34; TF34; Zinc finger protein 505; Zinc finger protein 93 (HTF34); Zinc finger protein 93; Zinc finger protein HTF34; ZNF505; ZNF93; ZNF93_HUMAN.

Cat:

SL13558R-FITC

Species Reactivity：

Human,

Immunogen：

KLH conjugated synthetic peptide derived from human ZBT24/ZNF45

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

71kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5 end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).

Function:
May be involved in transcriptional regulation.

Subcellular Location:
Nucleus.

DISEASE:
Expressed early during embryonic development.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 17 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Database links:

Entrez Gene: 81931 Human

Omim: 603975 Human

SwissProt: P35789 Human

Unigene: 301059 Human

Unigene: 723768 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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