background:
Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The C9orf85 gene product has been provisionally designated C9orf85 pending further characterization. There are three isoforms of C9orf85 that are produced as a result of alternative splicing events.
Database links:
Entrez Gene: 138241 Human
Entrez Gene: 66206 Mouse
Entrez Gene: 361740 Rat
SwissProt: Q96MD7 Human
SwissProt: Q9CQ90 Mouse
SwissProt: Q68FU5 Rat
Unigene: 534190 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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