background:
The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. The Zinc finger and BTB domain-containing protein 7C (ZBTB7C), also designated affected by papillomavirus DNA integration in ME36 cells protein 1 (APM-1), contains 1 BTB (POZ) domain and 4 C2H2-type zinc fingers. ZBTB7C is detected in normal cervical keratinocytes and may be a potential tumor suppressor gene against human papillomavirus (HPV) mediated cervical carcinogenesis.
Function:
The function of Anti-ZBTB7C has not yet been determined.
Tissue Specificity:
Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 4 C2H2-type zinc fingers.
Database links:
Entrez Gene: 201501 Human
Entrez Gene: 207259 Mouse
SwissProt: A1YPR0 Human
SwissProt: Q8VCZ7 Mouse
Unigene: 515388 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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