background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger and BTB domain-containing protein 5 (ZBTB5) is a 677 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZBTB5 contains a BTB domain, also known as a POZ domain, which inhibits DNA binding and mediates homotypic and heterotypic dimerization. Characteristics of the BTB domain suggest that ZBTB5 functions as a transcription regulator.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed with highest levels in brain.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 4 C2H2-type zinc fingers.
Database links:
Entrez Gene: 10773 Human
Entrez Gene: 241322 Mouse
Entrez Gene: 366029 Rat
Entrez Gene: 417108 Chicken
Entrez Gene: 540218 Cow
Omim: 605976 Human
SwissProt: Q0V8G8 Cow
SwissProt: Q15916 Human
SwissProt: Q8K088 Mouse
Unigene: 654596 Human
Unigene: 330182 Mouse
Unigene: 39069 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
