background:
BTBD4 is a 589 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD4 may play a role in transcription regulation.
Function:
ZBTB46 may be involved in transcriptional regulation. It contains one BTB (POZ) domain and two C2H2 type zinc fingers.
Tissue Specificity:
Nucleus (Potential).
Post-translational modifications:
Sumoylated. Desumoylation by PPPDE2 reverses transcriptional repression activity (By similarity).
Similarity:
Contains 1 BTB (POZ) domain.
Contains 2 C2H2-type zinc fingers.
Database links:
Entrez Gene: 140685 Human
Entrez Gene: 72147 Mouse
SwissProt: Q86UZ6 Human
SwissProt: Q8BID6 Mouse
Unigene: 585028 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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