background:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR114 (G protein-coupled receptor 114), also known as G-protein coupled receptor PGR27, is a 528 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and LN-TM7 subfamily. Containing one GPS domain and mapping to human chromosome 16, GPR114 functions as an orphan receptor. Chromosome 16 encodes over 900 genes, comprises nearly 3% of the human genome and is associated with both Rubinstein-Taybi syndrome and Crohn's disease.
Function:
Orphan receptor.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Database links:
Entrez Gene: 221188 Human
SwissProt: Q8IZF4 Human
Unigene: 187884 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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