background:
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. GPCR GPR85 is a member of this family (subfamily Orphan-A). GPCR GPR85 has been reported to be expressed in several areas of human and rat CNS (Matsumoto et al., 2000), as well as in genital organs. ESTs have been isolated from B-cell/lung/testis, brain, testis, and embryo libraries, as well as many mouse tissue libraries.
Function:
Orphan receptor.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 417775 Chicken
Entrez Gene: 54329 Human
Entrez Gene: 64450 Mouse
Entrez Gene: 100190819 Orangutan
Entrez Gene: 12820 Rat
Entrez Gene: 793299 Zebrafish
Omim: 605188 Human
SwissProt: P60893 Human
SwissProt: P60894 Mouse
SwissProt: Q5RBG7 Orangutan
SwissProt: P60895 Rat
SwissProt: Q9I919 Zebrafish
Unigene: 152009 Human
Unigene: 167625 Mouse
Unigene: 53985 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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